Students from the Autonomous University of Querétaro (UAQ) developed a method to detect kidney damage or symptoms of rejection after a transplant. The objective of the research of the students of the UAQ Faculty of Medicine (FM) is timely detecting health problems derived from kidney transplants; in addition to generating a risk profile in order to care for the patient in a timely manner with rescue therapies and thus improve their quality of life, the UAQ said in a statement.
Chronic rejection can occur one year from the date of transplantation, as the immunosuppression treatment is lowered. The only form to detect rejection nowadays is through studies and at that moment the patient already has some damage, said the student Hilda Edith Noriega Jiménez.
Given this scenario, the student said they look for biomarkers in the blood that detect kidney damage before the existence of other morphological changes. The research seeks to develop a non-invasive method that allows the detection of rejection in a stage where it is possible to make an opportune treatment.
This would help to form rescue therapies that decrease the progression of renal failure in transplanted patients, in order to considerably improve their quality of life. The research considers the information coming from the blood of the patients and molecular changes presented when there is a risk of insufficiency.
The study revealed that, between 2012 and 2017, of the 197 patients transplanted in Queretaro hospitals, half of those patients under 30 years old began with kidney problems without any justification.
“The problem of kidney disease is that it is silent and cannot be diagnosed if it is not sought, therefore, within the Faculty we begin another line of research that is to develop an early diagnostic method of this disease in young patients,” said Noriega Jiménez.