Scientists at the Federal University of Rio de Janeiro succeeded in halting the progress of Alzheimer’s in animal models and developed a new path to attack the disease. For the study, published in the American Journal of Neuroscience, the researchers applied a protein that is naturally produced in the brain, TGF beta 1, in animal models of Alzheimer’s disease. The treated rodents were able to remember certain objects that could not prior the treatment.
The researchers discovered the importance of this protein to maintain the electrical circuits of the brain. TGF beta 1 production is reduced in the elderly, generating a series of inflammations that disrupt the connection between neurons.
The research shows how a cell in the brain affected by Alzheimer’s partially recovers when TGF beta 1 protein is applied. Scientists from the Biomedical Sciences Institute of the University of Rio de Janeiro reported that the treatment reduced some symptoms of the disease, and the treated animals recovered their recent memory.
“What we did was barely a step for mid- and long-term treatment. It is a long way and certainly our work can contribute to it,” explained researcher Flávia Gomes, who participated in the project.
In an experiment, a mouse model of Alzheimer’s disease is placed in front of two equal objects and fails to react when one of the objects is replaced. However, once TGF beta 1 is injected, the mouse remembers the object unchanged and reacts to the new one.
Source: Agencia ID