A team of researchers from the Faculty of Higher Studies (FES) Cuautitlán, from the National Autonomous University of Mexico (UNAM), designed and developed a transdermal system for the treatment of dyslipidemias, a syndrome that involves high levels of cholesterol and triglycerides in the blood, a common problem in the Mexican population.
Traditionally, drugs for the treatment of this health condition are administered orally, which generates gastric irritation and fluctuations, that is, variations in medication intake, which causes therapeutic inefficiency and may cause strong adverse effects. This is what the UNAM scientists seek to avoid with their innovation, which already has a patent.
The transdermal system is formulated based on chitosan and poloxamer, helping to reduce cholesterol and triglycerides. Its application is easy for patients, since it can be placed without having to go to a specialist and can last between seven and 15 days, during which the drug is gradually released.
Dr. José Juan Escobar Chávez, responsible for the project, mentions that the adhesion of the patch has better results in places of little body hair and free of cosmetic treatments because it is impermeable, in addition to offering a local systemic effect of micro injection release.
“Because of the pace of life and the stress in which we are immersed, patches can be a more efficient treatment than the oral route, just because there are no fluctuations if you forget to take it or because you no longer complete the treatment,” says the doctor Escobar Chávez, who has five patents for systems to fight various diseases.
Before putting the transdermal device, the patient must pass over his skin a small roller that is composed of microneedles that pierce the superficial layer of the skin, which does not represent any discomfort.
The doctor of chemical sciences points out that dyslipidemias have been increasing in Mexico due to high rates of obesity, which have become a public health problem. In addition, high levels of cholesterol and triglycerides in the blood mean a potential cause of strokes and heart attacks, which represent the leading cause of death in the country.
Source: La Jornada