{"id":13122,"date":"2014-10-14T15:55:31","date_gmt":"2014-10-14T20:55:31","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=13122"},"modified":"2014-10-15T00:58:54","modified_gmt":"2014-10-15T05:58:54","slug":"lung-cancer-may-lie-dormant-for-two-decades","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/lung-cancer-may-lie-dormant-for-two-decades\/","title":{"rendered":"Lung Cancer May Lie Dormant for Two Decades"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-2684\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2013\/02\/cancerdepulmon1.jpg\" alt=\"cancerdepulmon\" width=\"196\" height=\"130\" \/>A recent study published in the journal <em>Science<\/em>, reports that <strong>lung cancer can remain dormant for more than 20 years before suddenly activate and becoming aggressive, a new study says<\/strong>.<\/p>\n<p><em>&#8220;This fascinating research highlights the need to find better ways to detect lung cancer earlier when it&#8217;s still following just one evolutionary path. If we can nip the disease in the bud and treat it before it has started traveling down different evolutionary routes, we could make a real difference in helping more people survive the disease,&#8221;<\/em> Professor Nic Jones, chief scientist at Cancer Research UK, said in a news release from the organization.<\/p>\n<p>Researchers analyzed lung cancers from seven patients &#8212; including smokers, former smokers and never smokers &#8212; and found that the i<strong>nitial genetic errors that cause the cancer can go undetected for many years<\/strong>.<\/p>\n<p><strong>This dormancy can end when new, additional genetic mistakes occur and trigger rapid cancer growth<\/strong>. During this sudden growth,<strong> different genetic errors appear in separate parts of the tumor<\/strong>. Each of these areas evolves differently, and each one is genetically unique, the scientists explained.<\/p>\n<p>The researchers also found that smoking causes many of the early genetic faults linked to lung cancer, but these become less important as the disease evolves. <strong>They said most of the new cancer-causing mutations are the results of a process controlled by a protein called APOBEC<\/strong>.<\/p>\n<p>According to the researchers, the large variety of genetic errors found within lung cancers explains why targeted treatments have had limited success against the disease.<\/p>\n<p>Charles Swanton, one of the study authors, said that survival rates from lung cancer remain &#8220;devastatingly low.<em>&#8221; However, he further explained: &#8220;By understanding how it develops we&#8217;ve opened up the disease&#8217;s evolutionary rule book in the hope that we can start to predict its next steps,&#8221;<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Through:<\/strong> <em>Health Library, Science<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A recent study published in the journal Science, reports that lung cancer can remain dormant for more than 20 years before suddenly activate and becoming aggressive, a new study says. &#8220;This fascinating research highlights the need to find better ways to detect lung cancer earlier when it&#8217;s still following just one evolutionary path. If we &#8230;<\/p>\n","protected":false},"author":1,"featured_media":2684,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15,12],"class_list":["post-13122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","tag-genomica","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/13122","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=13122"}],"version-history":[{"count":2,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/13122\/revisions"}],"predecessor-version":[{"id":13129,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/13122\/revisions\/13129"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/2684"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=13122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=13122"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=13122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}