{"id":15019,"date":"2015-04-17T10:55:43","date_gmt":"2015-04-17T16:55:43","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=15019"},"modified":"2015-04-20T09:59:39","modified_gmt":"2015-04-20T15:59:39","slug":"ipn-scientists-develop-antiviral-against-dengue","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/ipn-scientists-develop-antiviral-against-dengue\/","title":{"rendered":"IPN scientists develop antiviral against dengue"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"attachment-266x266 alignleft\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2014\/04\/57-Nueva-vacuna-contra-el-dengue-podria-beneficiar-a-m%C3%A1s-de-100-millones-de-personas-afectadas-cada-ano.jpg\" alt=\"57 Nueva vacuna contra el dengue podria beneficiar a m\u00e1s de 100 millones de personas afectadas cada ano\" width=\"196\" height=\"130\" \/>Scientists at the Center for Research and Advanced Studies (CINVESTAV) of the National Polytechnic Institute (IPN)<strong> develop antivirals to reduce or block infections caused by dengue<\/strong>, after finding that <strong>lipids and cholesterol helps the virus multiplying in the cells<\/strong>.<\/p>\n<p>Researcher at the Department of Molecular Infectomics and Pathogenesis, Rosa Maria del Angel, explained that &#8220;infected cells produce more cholesterol, because the virus needs it to multiply&#8221; so that if amounts of cholesterol and lipids produced by cell are limited, the virus infection is inhibited.<\/p>\n<p>This research, conducted for 17 years, initially focused on finding substances that the virus needs to multiply, and once the action of lipids and cholesterol on virus replication were detected, they began to develop antivirals.<\/p>\n<p>For their characterization and design, CINVESTAV specialists utilize <strong>compounds that reduce cholesterol levels and cellular lipids<\/strong>, <strong>decreasing the ability of the virus to infect human cells<\/strong>, such as macrophages and liver cells.<\/p>\n<p>At present, the research team is conducting a clinical study in patients to test the effectiveness of the antiviral developed in CINVESTAV.<\/p>\n<p>In a statement, the scientific institution explained that this disease is caused by any of the four serotypes of dengue virus and is transmitted to humans by mosquitoes of the genus Aedes.<\/p>\n<p><strong>Source:\u00a0<\/strong><em>Notimex<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists at the Center for Research and Advanced Studies (CINVESTAV) of the National Polytechnic Institute (IPN) develop antivirals to reduce or block infections caused by dengue, after finding that lipids and cholesterol helps the virus multiplying in the cells. Researcher at the Department of Molecular Infectomics and Pathogenesis, Rosa Maria del Angel, explained that &#8220;infected &#8230;<\/p>\n","protected":false},"author":1,"featured_media":10171,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15,11],"class_list":["post-15019","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","tag-vacunologia","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/15019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=15019"}],"version-history":[{"count":3,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/15019\/revisions"}],"predecessor-version":[{"id":15031,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/15019\/revisions\/15031"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/10171"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=15019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=15019"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=15019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}