{"id":17170,"date":"2016-02-15T12:00:49","date_gmt":"2016-02-15T18:00:49","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=17170"},"modified":"2016-02-15T18:14:08","modified_gmt":"2016-02-16T00:14:08","slug":"new-dopaminergic-delivery-method-shows-95-recovery-in-hemiparkinsonism-rats","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/new-dopaminergic-delivery-method-shows-95-recovery-in-hemiparkinsonism-rats\/","title":{"rendered":"New Dopaminergic Delivery Method Shows 95% Recovery in Hemiparkinsonism Rats"},"content":{"rendered":"<p><strong><a href=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/02\/hemiparkinsonismo-250x166.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-17180\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/02\/hemiparkinsonismo-250x166.jpg\" alt=\"hemiparkinsonismo-250x166\" width=\"196\" height=\"130\" \/><\/a>Hemiparkinsonism-hemiatrophy syndrome is a form of secondary Parkinsonism that presents with unilateral body Parkinsonism plus variable atrophy on the same side. Patients with this syndrome have shown good response to dopamine<\/strong>. However, <strong>there is still not an effective treatment to stop or slow its progression<\/strong>. <strong>This is because safe and continuous dopaminergic delivery into the brain across the blood brain barrier is a major hurdle for successful therapy<\/strong>.<\/p>\n<p>For this reason, Maria Guadalupe Valverde Aguilar, researcher at the National Polytechnic Institute (IPN), <strong>developed an inexpensive biomaterial<\/strong>, <strong>capable of releasing controlled doses of dopamine in the brain<\/strong>. <strong>Test performed on rat models of hemiparkinsonism showed that the delivery method helped the animals to recover their motor reflexes throughout their body<\/strong>.<\/p>\n<p>Valverde Aguilar said that the use of this biomaterial allowed 97 percent recovery in the hemiparkinsonism rats, which recovered the ability to perform activities such as swimming, walking, eating. After the treatment, the rodents stopped shaking and do erratic movements. Based on these results, she said, the new dopaminergic delivery method may offer a long-term therapeutic option.<\/p>\n<p>The method can supply two microliter of the solution into the brain of rats, which is enough for 6 months treatment. In the case of humans, she explained, personalized studies will have to be performed to determine the necessary quantity in each case.<\/p>\n<p>&#8220;<em>It is likely that the biomaterial can offer to rats and then humans an option to control the complications of this disease, stop its advance and avoid further deterioration of dopaminergic neurons<\/em>,&#8221; Valverde Aguilar said.<\/p>\n<p>Behavioral and histologically studies were performed in the hemiparkinsonism rats after using the delivery method for periods of six months. Likewise, the oxidation process in the samples was monitored by infrared spectroscopy and optical absorption. They are also characterized by high resolution microscopy and x-ray diffraction.<\/p>\n<p>Valverde Aguilar said another objective of this research is prolonging the life of the biomaterial with dopamine through delaying its oxidation processes in vitro, when exposed to the environment and to natural sunlight.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>Agencia ID<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hemiparkinsonism-hemiatrophy syndrome is a form of secondary Parkinsonism that presents with unilateral body Parkinsonism plus variable atrophy on the same side. Patients with this syndrome have shown good response to dopamine. However, there is still not an effective treatment to stop or slow its progression. This is because safe and continuous dopaminergic delivery into the &#8230;<\/p>\n","protected":false},"author":1,"featured_media":17180,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-17170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/17170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=17170"}],"version-history":[{"count":2,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/17170\/revisions"}],"predecessor-version":[{"id":17181,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/17170\/revisions\/17181"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/17180"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=17170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=17170"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=17170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}