{"id":18949,"date":"2016-11-06T13:00:09","date_gmt":"2016-11-06T19:00:09","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=18949"},"modified":"2016-11-07T16:37:02","modified_gmt":"2016-11-07T22:37:02","slug":"ipn-researchers-study-a-plant-to-combat-breast-cancer","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/ipn-researchers-study-a-plant-to-combat-breast-cancer\/","title":{"rendered":"IPN Researchers Study a Plant to Combat Breast Cancer"},"content":{"rendered":"<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-18959\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/11\/decatropis-bicolor.jpg\" alt=\"decatropis-bicolor\" width=\"196\" height=\"130\" srcset=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/11\/decatropis-bicolor.jpg 600w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/11\/decatropis-bicolor-300x199.jpg 300w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2016\/11\/decatropis-bicolor-250x166.jpg 250w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/>A group of scientist of the National Polytechnic Institute (IPN) are studying a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico<\/strong>.<\/p>\n<p><strong>Essential oil from hydrodestillation of leaves of\u00a0a plant called Aranto (<em>Decatropis bicolor<\/em>), endemic of the State of Hidalgo, was studied for its biological activity against two breast cancer cell lines<\/strong>, according with a paper published in <em>BMC Complementary and Alternative Medicine.<\/em><\/p>\n<p>The study showed a <strong>relevant cytotoxic effect of the essential oil towards MDA-MB-231 cell line<\/strong> (which is a type of human breast cancer cells). The researchers found apoptotic (programed cell death) characteristics in the treated cells like cell size reduction, membrane blebbing and apoptotic bodies. In addition, the apoptotic rate significantly increased as well as DNA fragmentation.<\/p>\n<p>The IPN researchers found, through western blot analysis, that the <strong>essential oil induced apoptosis in the MDA-MB-231 cells via intrinsic pathways due to the activation of Bax<\/strong>, caspases 9 and 3.<\/p>\n<p>&#8220;<em>At first we did not know exactly where the effect was. We knew that used for treatment of breast cancer, but not metabolites that may be inducing a positive effect<\/em>,\u201d said Maria del Consuelo Gomez Garcia, researcher at the IPN\u2019s National School of Medicine and Homeopathy.<\/p>\n<p>According with the paper, <strong>phytochemical analysis of the <em>Decatropis bicolor<\/em> essential oil showed the presence of twenty-three compounds<\/strong>. Major components of the oil were 1,5-cyclooctadiene,3-(methyl-2)propenyl (18.38 %), \u03b2-terpineol (8.16 %) and 1-(3-methyl-cyclopent-2-enyl)-cyclohexene (6.12 %).\u201d<\/p>\n<p>\u201c<em>Something important we found when studing this plant is that it has a significant cytotoxic effect, because a low concentration of this essential oil is needed to remove at least 50 percent of tumor cells<\/em>,&#8221; Gomez Garcia said.<\/p>\n<p>&#8220;<em><strong>One of the objectives of this research is synthesizing a compound that can be evaluated in rats and mice to establish its mechanism of action, and use nano-encapsulation technology<\/strong>. This would <strong>allow increasing and targeting its effect towards tumor tissues<\/strong>, as well as expanding the knowledge on herbal medicines present in the Mexican medicinal flora<\/em>,\u201d said Consuelo Gomez said in a statement.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>Notimex, BMC Complementary and Alternative Medicine<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group of scientist of the National Polytechnic Institute (IPN) are studying a plant that has been traditionally used for the treatment of breast cancer in some communities of Mexico. Essential oil from hydrodestillation of leaves of\u00a0a plant called Aranto (Decatropis bicolor), endemic of the State of Hidalgo, was studied for its biological activity against &#8230;<\/p>\n","protected":false},"author":7,"featured_media":18959,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-18949","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/18949","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=18949"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/18949\/revisions"}],"predecessor-version":[{"id":18960,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/18949\/revisions\/18960"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/18959"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=18949"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=18949"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=18949"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}