{"id":21891,"date":"2017-11-14T13:00:47","date_gmt":"2017-11-14T19:00:47","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=21891"},"modified":"2017-11-15T11:57:34","modified_gmt":"2017-11-15T17:57:34","slug":"a-disorder-in-thyroid-hormones-can-lead-to-emotional-problems","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/a-disorder-in-thyroid-hormones-can-lead-to-emotional-problems\/","title":{"rendered":"A disorder in thyroid hormones can lead to emotional problems"},"content":{"rendered":"

\"\"Thyroid hormones are essential for proper brain development and function. A new study in mice showed that the absence of the deiodinase type 2 protein, essential for having correct levels of thyroid hormone in the brain, triggers emotional disorders probably derived from a state of cerebral hypothyroidism<\/strong>.<\/p>\n

A deficiency of thyroid hormones in the brain can lead to serious neurological disorders and psychiatric disorders, particularly mood disorders<\/strong>. This is because thyroid hormones play an essential role in the development and function of the central nervous system<\/strong>.<\/p>\n

The thyroid gland mainly synthesizes the T4 prohormone, but most of the thyroid hormones\u2019 actions are mediated by T3, the main active form genomically<\/strong>. In the brain, type 2 deiodinase (D2) is of great importance, and its activity depends on the local formation of T3 from T4<\/strong>.<\/p>\n

Now, a group of scientists from the Biomedical Research Institute \u2018Alberto Sols<\/em>\u2019, a joint center of the Autonomous University of Madrid (UAM), the Superior Council of Scientific Investigations (CSIC), and the Department of Psychobiology at the National University for Distance Education (UNED), conducted a study to analyze the consequences of D2 deficiency<\/strong>.<\/p>\n

Specifically, the team of researchers assessed anxiety behaviors and learning and memory capabilities in D2-deficient adult mice, using behavioral testing<\/strong>. They also studied the thyroid status in two brain regions involved in these behavioral processes: the amygdala and hippocampus<\/strong>.<\/p>\n

The findings, published in Psychoneuroendocrinology<\/em>, revealed that D2-deficient mice did not showed alterations in learning and spatial memory, which depend from the hippocampus<\/strong>. However, the mice did show emotional dysfunctions: they showed an enhanced fear memory, plus an increase in anxiety behavior<\/strong>. All these processes depend on a proper function of the amygdala, a region of the limbic system.<\/p>\n

The assessment of thyroid status of the amygdala and hippocampus revealed that both brain structures have a state of hypothyroidism in D2-deficient mice. In the amygdala, this state of hypothyroidism appears to be associated with decreased expression of a calcium binding protein, Calb2, which could be affecting neuronal activity in the structure; and thus, it may contribute to the observed emotional disorders<\/strong>, explained the researchers.<\/p>\n

These results highlight the importance of maintaining appropriate levels of thyroid hormone in the brain<\/strong>, particularly through local generation of T3, to avoid emotional disorders.<\/p>\n

Furthermore, this research may help to understand the possible emotional disturbances present in humans with polymorphisms in the gene encoding D2 (DIO2)<\/strong>.<\/p>\n

 <\/p>\n

Source: <\/strong>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Thyroid hormones are essential for proper brain development and function. A new study in mice showed that the absence of the deiodinase type 2 protein, essential for having correct levels of thyroid hormone in the brain, triggers emotional disorders probably derived from a state of cerebral hypothyroidism. A deficiency of thyroid hormones in the brain …<\/p>\n","protected":false},"author":7,"featured_media":21897,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15,12],"class_list":["post-21891","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","tag-genomica","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/21891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=21891"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/21891\/revisions"}],"predecessor-version":[{"id":21898,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/21891\/revisions\/21898"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/21897"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=21891"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=21891"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=21891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}