{"id":22304,"date":"2018-01-15T13:00:43","date_gmt":"2018-01-15T19:00:43","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=22304"},"modified":"2018-01-15T12:10:19","modified_gmt":"2018-01-15T18:10:19","slug":"new-determinants-involved-in-the-development-of-nafld","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/new-determinants-involved-in-the-development-of-nafld\/","title":{"rendered":"New determinants involved in the development of NAFLD"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-22316\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/01\/Nuevos-determinantes-implicados-desarrollo-higado-graso-no-alcoholico.jpg\" alt=\"\" width=\"196\" height=\"130\" srcset=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/01\/Nuevos-determinantes-implicados-desarrollo-higado-graso-no-alcoholico.jpg 600w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/01\/Nuevos-determinantes-implicados-desarrollo-higado-graso-no-alcoholico-300x199.jpg 300w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/01\/Nuevos-determinantes-implicados-desarrollo-higado-graso-no-alcoholico-250x166.jpg 250w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/>A new study by Manuel V\u00e1zquez Carrera, researcher at the Spanish Biomedical Research Centre in Network for Diabetes and Associated Metabolic Disorders (CIBERDEM) and the University of Barcelona, allowed <strong>discovering new factors involved in the development of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder which incidence has reached epidemic proportions in the world<\/strong>.<\/p>\n<p>This condition includes a large variety of liver abnormalities, ranging from excessive accumulation of triglycerides in the liver to nonalcoholic steatohepatitis.<\/p>\n<p>Scientists have shown that <strong>very low density lipoprotein receptor (VLDLR) which plays an important role in the development of hepatic steatosis, is regulated by PPARb\/d receptor and FGF21 hormone<\/strong>.<\/p>\n<p>Using different cellular and animal models, the authors showed that <strong>PPARb\/d and FGF21 deficiency favor increased VLDLR levels and the consequent development of hepatic steatosis<\/strong>.<\/p>\n<p>Also, the researchers <strong>observed in liver biopsies of patients with hepatic steatosis increased VLDLR levels, accompanied by lower activity and levels of PPARb\/d<\/strong>. Together, these <strong>data suggest that modulation of PPARb\/d or FGF21 could have a therapeutic effect in hepatic steatosis<\/strong>, by regulating the VLDLR levels.<\/p>\n<p>The study, which results were recently published in <em>Molecular Metabolism<\/em>, were conducted in collaboration with CIBERDEM researchers from several institutions, including Angela M. Valverde (IIBM UAM-CSIC), Joan Carles Escol\u00e0-Gil and Francisco Blanco-Vaca (Hospital Sant Pau) among others, as well as researchers from CIBEROBN group of Francesc Villarroya (UB), and other groups led by Walter Wahli and Reza Zali.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study by Manuel V\u00e1zquez Carrera, researcher at the Spanish Biomedical Research Centre in Network for Diabetes and Associated Metabolic Disorders (CIBERDEM) and the University of Barcelona, allowed discovering new factors involved in the development of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder which incidence has reached epidemic proportions in the &#8230;<\/p>\n","protected":false},"author":7,"featured_media":22316,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-22304","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/22304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=22304"}],"version-history":[{"count":5,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/22304\/revisions"}],"predecessor-version":[{"id":22317,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/22304\/revisions\/22317"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/22316"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=22304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=22304"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=22304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}