{"id":23695,"date":"2018-08-29T13:00:29","date_gmt":"2018-08-29T19:00:29","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=23695"},"modified":"2018-08-29T13:14:40","modified_gmt":"2018-08-29T19:14:40","slug":"study-found-new-pathway-involved-in-neuronal-regeneration","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/study-found-new-pathway-involved-in-neuronal-regeneration\/","title":{"rendered":"Study found new pathway involved in neuronal regeneration"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-23709\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/08\/nueva-via-regeneracion-neuronal-2.jpg\" alt=\"\" width=\"196\" height=\"130\" srcset=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/08\/nueva-via-regeneracion-neuronal-2.jpg 600w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/08\/nueva-via-regeneracion-neuronal-2-300x199.jpg 300w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/08\/nueva-via-regeneracion-neuronal-2-250x166.jpg 250w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/>A new study conducted by a team of researchers at Boston University School of Medicine (BUSM) <strong>found a new pathway involved in neuronal regeneration<\/strong>. The BUSM researchers observed that <strong>they could alter neuronal metabolism by changing the levels of sugars that cover the surface of proteins (called O-GlcNAc modifications)<\/strong>; and therefore, they <strong>were able to significantly enhance neuronal regeneration after injury<\/strong>. This <strong>discovery may help opening new lines of research to managing brain and spinal cord injuries<\/strong>.<\/p>\n<p>The study, published in <em>Cell Reports,<\/em> <strong>used animal models which O-GlcNAc levels were absent or abundant<\/strong>. Then, <strong>they produce injures to individual neurons using a laser in each of the models, and measured the neuronal regeneration<\/strong>.<\/p>\n<p>Interestingly, the researchers found that <strong>both increased and decreased levels of O-GlcNAc enhanced neuronal regeneration<\/strong>. The researchers also found that this may be the result of a change in the metabolism of the neuron during regeneration, demonstrating the importance of O-GlcNAc in coordinating the response to neuronal injury and its regeneration.<\/p>\n<p>The research may open the possibility to develop new treatments for conditions like spinal cord injuries. &#8220;<strong><em>Using this as a model, we can now find other genes or drugs that act on metabolism to ultimately enhance regeneration and recovery after traumatic neuronal injury<\/em><\/strong>,&#8221; explained corresponding author Christopher V. Gabel, PhD, associate professor of Physiology and Biophysics at BUSM.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>Science Daily<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A new study conducted by a team of researchers at Boston University School of Medicine (BUSM) found a new pathway involved in neuronal regeneration. The BUSM researchers observed that they could alter neuronal metabolism by changing the levels of sugars that cover the surface of proteins (called O-GlcNAc modifications); and therefore, they were able to &#8230;<\/p>\n","protected":false},"author":7,"featured_media":23709,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-23695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=23695"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23695\/revisions"}],"predecessor-version":[{"id":23710,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23695\/revisions\/23710"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/23709"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=23695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=23695"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=23695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}