{"id":23741,"date":"2018-09-03T13:00:06","date_gmt":"2018-09-03T19:00:06","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=23741"},"modified":"2018-09-03T13:31:55","modified_gmt":"2018-09-03T19:31:55","slug":"a-computer-analysis-identifies-a-new-clinical-phenotype-of-severe-malaria","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/a-computer-analysis-identifies-a-new-clinical-phenotype-of-severe-malaria\/","title":{"rendered":"A computer analysis identifies a new clinical phenotype of severe malaria"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-23757\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/09\/modelo-compu-malaria-grave-2.jpg\" alt=\"\" width=\"196\" height=\"130\" srcset=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/09\/modelo-compu-malaria-grave-2.jpg 600w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/09\/modelo-compu-malaria-grave-2-300x199.jpg 300w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2018\/09\/modelo-compu-malaria-grave-2-250x166.jpg 250w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/>In 2016, <strong>malaria caused nearly half a million deaths, mostly in children<\/strong>. <strong>New research could help reduce the associated mortality thanks to a computer analysis that describes a new clinical phenotype of this disease<\/strong>.<\/p>\n<p>There are more clinical phenotypes of severe malaria than those defined by the World Health Organization (WHO), according to a study led by ISGlobal. The results indicate that <strong>heart failure can be a pathogenic mechanism in severe malaria, which would have implications in the clinical management of this type of patients<\/strong>.<\/p>\n<p>Despite the achievements made in recent decades, it is estimated that <strong>in 2016 malaria caused nearly half a million deaths, mostly in children<\/strong>. The definition of severe malaria was established to identify those children at greater risk of dying, but in reality it is a complex and heterogeneous disease that does not always respond to the indicated treatments.<\/p>\n<p>The team led by Climent Casals-Pascual, researcher at ISGlobal and the University of Oxford, <strong>applied a network-based computer analysis to identify biologically relevant phenotypes different from the three types currently defined by WHO<\/strong> (cerebral malaria, respiratory distress and anemia due to severe malaria).<\/p>\n<p>To do this, they conducted a &#8216;network-based group analysis&#8217; using clinical data from almost 3,000 Gambian children hospitalized for malaria. They found that mortality is higher in groups with more heterogeneous phenotypes.<\/p>\n<p>In addition, <strong>they identified four groups (or clusters) of patients with respiratory distress and severe anemia in whom the increase in liver size was associated with increased mortality<\/strong>. The analysis of proteins in the plasma of these patients revealed that this is probably due to deficiencies in cardiac function.<\/p>\n<p>&#8220;<strong><em>Our results indicate that heart failure should be considered again as a pathogenic mechanism in severe malaria<\/em><\/strong>,&#8221; explains Casals-Pascual, &#8220;and the standard treatment may be inappropriate for these patients.&#8221;<\/p>\n<p>This type of systems approach based on clinical manifestations &#8220;can be very useful to identify new phenotypes and mechanisms, and therefore better therapeutic options for complex diseases&#8221;, adds the researcher.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In 2016, malaria caused nearly half a million deaths, mostly in children. New research could help reduce the associated mortality thanks to a computer analysis that describes a new clinical phenotype of this disease. There are more clinical phenotypes of severe malaria than those defined by the World Health Organization (WHO), according to a study &#8230;<\/p>\n","protected":false},"author":7,"featured_media":23757,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15,55],"class_list":["post-23741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","tag-tecnologicas","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=23741"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23741\/revisions"}],"predecessor-version":[{"id":23758,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23741\/revisions\/23758"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/23757"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=23741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=23741"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=23741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}