{"id":23759,"date":"2018-09-04T13:00:45","date_gmt":"2018-09-04T19:00:45","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=23759"},"modified":"2018-09-04T15:31:31","modified_gmt":"2018-09-04T21:31:31","slug":"a-cellular-trojan-horse-awakens-the-antitumor-immune-system","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/a-cellular-trojan-horse-awakens-the-antitumor-immune-system\/","title":{"rendered":"A cellular Trojan horse awakens the antitumor immune system"},"content":{"rendered":"

\"\"Spanish researchers have shown in mice the antitumor effect of a type of virus hidden in mesenchymal stem cells<\/strong>. The therapy manages to activate the subject’s immune response and opens the door to the possibility of a universal treatment<\/strong>. The work has just been published in Cancer Immunology<\/em>.<\/p>\n

A novel therapy, known as Celyvir, has demonstrated the antitumor effect of oncolytic viruses \u2014capable of infecting and decomposing cancer cells\u2014 hidden in mesenchymal stem cells<\/strong>, i.e. those that can give rise to several types of cells of skeletal tissues, like cartilage, bone and fat.<\/p>\n

The research, conducted in mice in the Cell Biotechnology Unit of the Carlos III<\/em> Health Institute, combines cells and viruses to act as a kind of cellular Trojan horse that awakens the antitumor immune system<\/strong>.<\/p>\n

“Our work has confirmed in mice that the mesenchymal stem cells that carry the antitumor virus could be obtained both from the patient himself (syngeneic cells) and from a donor (allogeneic cells), reducing the volume of the tumor by 35%<\/em>,” explains \u00c1lvaro Morales , lead author of the study.<\/p>\n

In both cases, the treatment not only succeeded in activating the immune response, but also increased the infiltration of certain anticancer immune cells (the so-called N2 antitumor neutrophils)<\/strong> in the treated cancers.<\/p>\n

Previous work has indicated that this greater infiltration of the immune system in the tumor is extensively related to a better prognosis of the disease and a greater response to other immunotherapies.<\/p>\n

A universal treatment<\/h3>\n

Oncolytic viruses are those that selectively replicate in tumor cells, destroying them<\/strong>. The problem with this therapy is that the virus does not reach the tumor on its own, since the immune system usually exerts an antiviral response against it.<\/p>\n

To solve it, experts have used mesenchymal stem cells, transporting those viruses inside them as if they were a cellular Trojan horse<\/strong>. In this way, the oncolytic virus reaches the tumor within the stem cells themselves, where it is released and produces a greater antitumor response<\/strong>.<\/p>\n

“The results open the possibility of producing a universal treatment of mesenchymal stem cells as transporters of the oncolytic virus without the need to obtain them from patients, which facilitates the speed and availability of this viroimmunotherapy<\/em>,” concludes Morales.<\/p>\n

 <\/p>\n

Source: <\/strong>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

Spanish researchers have shown in mice the antitumor effect of a type of virus hidden in mesenchymal stem cells. The therapy manages to activate the subject’s immune response and opens the door to the possibility of a universal treatment. The work has just been published in Cancer Immunology. A novel therapy, known as Celyvir, has …<\/p>\n","protected":false},"author":7,"featured_media":23763,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-23759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=23759"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23759\/revisions"}],"predecessor-version":[{"id":23764,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/23759\/revisions\/23764"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/23763"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=23759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=23759"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=23759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}