{"id":25202,"date":"2019-03-31T12:00:33","date_gmt":"2019-03-31T18:00:33","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=25202"},"modified":"2019-04-01T12:17:09","modified_gmt":"2019-04-01T18:17:09","slug":"researchers-found-new-molecular-mechanism-for-pancreatic-repair","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/researchers-found-new-molecular-mechanism-for-pancreatic-repair\/","title":{"rendered":"Researchers found new molecular mechanism for pancreatic repair"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-25234\" src=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2019\/03\/nuevo-mecanismo-molecular-implicado-reparacion-pancreatica-2.jpg\" alt=\"\" width=\"196\" height=\"130\" srcset=\"http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2019\/03\/nuevo-mecanismo-molecular-implicado-reparacion-pancreatica-2.jpg 600w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2019\/03\/nuevo-mecanismo-molecular-implicado-reparacion-pancreatica-2-300x199.jpg 300w, http:\/\/www.salud.carlosslim.org\/english2\/wp-content\/uploads\/2019\/03\/nuevo-mecanismo-molecular-implicado-reparacion-pancreatica-2-250x166.jpg 250w\" sizes=\"auto, (max-width: 196px) 100vw, 196px\" \/>Scientists from the University of Malaga (UMA) have shown that <strong>after a pancreatic damage, the Wilms&#8217; tumor suppressor (Wt1) gene is activated in the cells called stellate \u2014the most important cell type involved in the formation of scar tissue in response to liver and pancreas damage<\/strong>.<\/p>\n<p>&#8220;<strong><em>Without the activation of Wt1 these cells cannot fulfill their function<\/em><\/strong>,&#8221; says Ram\u00f3n Mu\u00f1oz-Ch\u00e1puli, who also points out the <strong>crucial role that these cells play in the progression of pancreatic cancer, since they become allies of the tumors<\/strong>.<\/p>\n<p>The results of the UMA study reveal that the <strong>Wt1 gene is not only necessary for the normal maintenance of the pancreas, but also for its repair after damage<\/strong>.<\/p>\n<p>The <strong>Wilms&#8217; tumor suppressor gene encodes a protein that acts as a master regulator of the function of many other genes<\/strong>; therefore, as these experts say, it is <strong>very important in processes of embryonic development of various organs such as the kidneys, the spleen and the heart<\/strong>. Likewise, in recent years it has also been confirmed that this functional relevance extends to adult life.<\/p>\n<p>This study, published in <em>PLOS Genetics<\/em>, includes the participation of professors Mu\u00f1oz-Ch\u00e1puli and Rita Carmona, UMA researcher Laura Ariza, and Anabel Rojas from the Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER).<\/p>\n<p>For the authors, the team&#8217;s <strong>next step will be to move towards new functions of the Wt1 gene in cardiac development and in the adult heart<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Scientists from the University of Malaga (UMA) have shown that after a pancreatic damage, the Wilms&#8217; tumor suppressor (Wt1) gene is activated in the cells called stellate \u2014the most important cell type involved in the formation of scar tissue in response to liver and pancreas damage. &#8220;Without the activation of Wt1 these cells cannot fulfill &#8230;<\/p>\n","protected":false},"author":7,"featured_media":25234,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15,12],"class_list":["post-25202","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","tag-genomica","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25202","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=25202"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25202\/revisions"}],"predecessor-version":[{"id":25236,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25202\/revisions\/25236"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/25234"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=25202"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=25202"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=25202"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}