{"id":25784,"date":"2019-06-27T12:00:52","date_gmt":"2019-06-27T18:00:52","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=25784"},"modified":"2019-06-27T13:26:00","modified_gmt":"2019-06-27T19:26:00","slug":"cancer-cells-ingest-recycled-vitamin-c-to-survive","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/cancer-cells-ingest-recycled-vitamin-c-to-survive\/","title":{"rendered":"Cancer cells ingest recycled vitamin C to survive"},"content":{"rendered":"

\"\"Researchers from the University of Concepci\u00f3n (Chile) have discovered that cancer cells satisfy their nutritional by ingesting recycled vitamin C<\/strong>. As described in a paper published in the journal Free Radical Biology and Medicine<\/em>, it is a key mechanism that these cells use to survive<\/strong>.<\/p>\n

The research details how cancer cells acquire oxidized vitamin C (dehydroascorbic acid or DHA), which is found in high concentrations around tumors, transports it inside and converts it into reduced vitamin C, (AA, ascorbic acid), which has an antioxidant function<\/strong>.<\/p>\n

“We discovered an unexpected characteristic of tumor cells: they are capable of accumulating large amounts of vitamin C inside them, compared to normal cells<\/em>,” explains Dr. Coralia Rivas, director of the research.<\/p>\n

“We tested tumor cells from breasts, prostate, leukemia, and all these cell lines fulfilled this characteristic<\/em>,” says the researcher. For Dr. Rivas, the most important thing is that this mechanism means that vitamin C, as an antioxidant, “would be protecting the tumor cells<\/em>.”<\/strong><\/p>\n

Unlike normal cells, tumor cells have a transporter that takes this reduced vitamin C and carries it to the mitochondria (responsible for supplying energy for cellular activity). “It is a mechanism by which tumor cells become immortal, despite being surrounded by oxidizing signals that would otherwise induce their death<\/em><\/strong>,” says Carola Mu\u00f1oz, PhD in Biological Sciences and member of the research team.<\/p>\n

The transporter, called SVCT2<\/strong>, “would allow the mitochondria of the tumor to transfer the vitamin to its interior and, in this way, avoid the death of the cancer cell<\/em><\/strong>,” adds Mu\u00f1oz, who noted that this transporter is located inside the cell and not on the surface, as expected.<\/p>\n

Dr. Rivas said the next step of the research is to create a pharmacological solution that inhibits the transportation of the vitamin inside tumor cells<\/strong>, which means finding molecules that can serve to block the entry of vitamin C to the mitochondria.<\/p>\n

Vitamin C must be part of our diet<\/h3>\n

“It is not about removing vitamin C from the diet, but what we have to do is eliminate the ability of the cell to survive using this mechanism<\/em>,” says Mu\u00f1oz. Vitamin C “is a fundamental element for any living being, and in the case of humans, yes or yes, it must be in the diet<\/em>,” Dr. Rivas said. By eliminating it from your diet “you will rather cause an extremely complicated disease and you be left unprotected<\/em>,” warns the scientist.<\/p>\n

 <\/p>\n

Source: <\/strong>Agencia ID<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Researchers from the University of Concepci\u00f3n (Chile) have discovered that cancer cells satisfy their nutritional by ingesting recycled vitamin C. As described in a paper published in the journal Free Radical Biology and Medicine, it is a key mechanism that these cells use to survive. The research details how cancer cells acquire oxidized vitamin C …<\/p>\n","protected":false},"author":7,"featured_media":25814,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-25784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=25784"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25784\/revisions"}],"predecessor-version":[{"id":25815,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/25784\/revisions\/25815"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/25814"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=25784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=25784"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=25784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}