{"id":26731,"date":"2019-11-09T12:00:23","date_gmt":"2019-11-09T18:00:23","guid":{"rendered":"http:\/\/www.salud.carlosslim.org\/english2\/?p=26731"},"modified":"2019-11-11T12:02:04","modified_gmt":"2019-11-11T18:02:04","slug":"a-key-gene-in-hereditary-alzheimers-regulates-the-development-of-neurons","status":"publish","type":"post","link":"http:\/\/www.salud.carlosslim.org\/english2\/a-key-gene-in-hereditary-alzheimers-regulates-the-development-of-neurons\/","title":{"rendered":"A key gene in hereditary Alzheimer&#8217;s regulates the development of neurons"},"content":{"rendered":"<p>An international team of researchers <strong>described a new pathway that promotes the differentiation of neurons<\/strong>. This <strong>mechanism is regulated by the presenilin gene (mutated in most cases of hereditary Alzheimer&#8217;s disease) through a protein that is involved in the development of cancer<\/strong>. The finding demonstrates that <strong>there is a common mechanism between neurodegeneration that occurs in Alzheimer&#8217;s and cell proliferation in cancer<\/strong>.<\/p>\n<p>Age is the most important factor in the development of neurodegenerative and cancer. In addition, epidemiological studies indicate that t<strong>here is an inverse relationship between having Alzheimer&#8217;s disease and cancer<\/strong>, although the mechanisms that connect both pathologies are unknown.<\/p>\n<p>An international team of researchers led by Carlos Saura, from the Institut de Neuroci\u00e8ncies of the Autonomous University of Barcelona (UAB), has <strong>discovered an essential mechanism for the growth of axons in neuron, a key process for the correct development of the brain<\/strong>.<\/p>\n<p>According to the study, published in the journal <em>eLife<\/em>, this <strong>mechanism requires presenilin<\/strong>, the main mutated gene in hereditary Alzheimer&#8217;s disease. <strong>Its malfunction in these patients is what causes the production of cerebral b-amyloid<\/strong>, characteristic of this pathology.<\/p>\n<p>In this study, researchers demonstrate that <strong>presenilin is essential for regulating neurons during brain development, and interestingly through the EphA3 receptor, a protein involved in various cancers<\/strong>. The relevance of the study is that it demonstrates the existence for the first time of this new cellular mechanism that connects neurodegeneration and cancer.<\/p>\n<p>\u201c<em>The <strong>discovery of this new signaling pathway is very relevant in the study of neurological diseases in which the morphology of the neuronal axon is altered<\/strong>. In addition, the implications of the study go beyond the brain since the mechanism involves EphA receptors that play a key role in cancer<\/em>,\u201d explains the study&#8217;s first author, M\u00edriam Javier.<\/p>\n<p>According to Saura, this <strong>research allows us to be optimistic in the development of common therapeutic strategies to combat neurological diseases and cancer<\/strong>.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Source: <\/strong><em>SINC<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>An international team of researchers described a new pathway that promotes the differentiation of neurons. This mechanism is regulated by the presenilin gene (mutated in most cases of hereditary Alzheimer&#8217;s disease) through a protein that is involved in the development of cancer. The finding demonstrates that there is a common mechanism between neurodegeneration that occurs &#8230;<\/p>\n","protected":false},"author":7,"featured_media":26764,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[3],"tags":[15],"class_list":["post-26731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-en-la-salud","tag-casalud","cat-3-id","has_thumb"],"_links":{"self":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/26731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/comments?post=26731"}],"version-history":[{"count":4,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/26731\/revisions"}],"predecessor-version":[{"id":26765,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/posts\/26731\/revisions\/26765"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media\/26764"}],"wp:attachment":[{"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/media?parent=26731"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/categories?post=26731"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.salud.carlosslim.org\/english2\/wp-json\/wp\/v2\/tags?post=26731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}