labio-leporino-celulas-madre.2Two doctors from the Maimonides University in Buenos Aires, Guillermo Trigo and Gustavo Moviglia, are the first to recover missing tissues caused by cleft lip and cleft palate through the use of stem cells, reported the Cord Blood Bank in a statement.

The incidence of both conditions is one case per thousand babies. In 50% of the cases both conditions occurs simultaneously with a similar proportion between men and women.

Cleft lip without cleft palate is more common in men, occurs in a relation of seven men per three women, and represents 25 percent of cases. While the cleft palate without cleft lip represents 25 percent of the remaining cases and is more common in women.

Frequently, the treatment requires at least four surgeries, and is important since this malformation is not only an aesthetic problem, but also affect facial functions, causing difficulty for speaking, swallowing and breathing, among others.

With the use of stem cells, the Argentinian doctors, Trigo and Moviglia, were able to improve healing and natural bone recovery processes, with much better results than those from usual grafting.

We are replacing the surgeries are that were usually made with tissue engineering. In 2007 we perform our first case,” said Trigo. He explained that their first patient was the son of a surgeon who was so confident in the method that asked them to perform the surgery in the boy and placed the stem cells.

He added that the results were not only good, but even surprised themselves, so they decided to continue this line of research.

In recent years, these procedures with stem cells were applied to nine patients, all of them in Argentina, but Moviglia and Trigo now seek to spread the process to more countries through agreements with other research centers.

For now, the researchers applied this cell therapy only to newborns, as long as the umbilical cord cells were conserved and they have not undergone prior surgical procedures.

We use an early technique by French surgeon who operates the palate first and then at four months and six months the lip. Within the first six months of life it is practically completed all the primary surgery. To this technique we add tissue engineering,” said Trigo.

With stem cells, the patient himself is who generates the bone naturally and spontaneously from baby, so that there is no memory of the process or psychological burden for having born with a malformation,” he added.

Dr. Moviglia insisted on the need to create social awareness of the benefits of preserving stem cells from the umbilical cord of every newborn, for both treating congenital lesions and curing future diseases.


Source: Notimex