According with a study performed at the Division of Biosciences and Nephrology in University College London (UCL), a ‘junk food’ diet, or as called by the researchers “cafeteria diet) can cause similar blood sugar levels and cause as much damage to the kidney as diabetes.
Type 2 diabetes occurs when the body cannot properly use insulin, a hormone that regulates blood sugar. This problem increases blood glucose levels causing serious long-term damage to the organs, leading to diseases such as diabetic kidney disease. If researchers would find a treatment to block renal glucose reabsorption, blood sugar levels may decrease.
For the study, published in the journal Experimental Physiology, the researchers induced type I and type II diabetes in rats, which were fed with standard rat chow and water. These rats were compared with two other groups of diet-induced obesity rat models (‘junk food’ or high-fat), in order to study how this may affect glucose transporters in the kidney.
For the high-fat diet model, male Wistar rats were fed with a rat chow with 60% of fat over a 5-week period. For the ‘junk-food’ model, male Wistar rats were fed chow supplemented with junk food over an 8-week period. The junk-food diet consisted of a choice of palatable, processed foods with high fat and/or high sugar content, including potato crisps, flapjacks, cheese, marshmallows, muffins, doughnut, biscuits and chocolate bars.
The effect of these diets on blood sugar levels and the different glucose transporters in the kidneys were tested by the researchers, and then compared with the rat models of type 1 and type 2 diabetes.
The researchers found that both, the high-fat diet model and the ‘junk-food’ model, showed increased numbers of their regulatory proteins and certain types of glucose transporters (GLUT and SGLT), similarly to type 2 diabetic rats.
Source: Agencia ID