The creation of artificially produced sperm and ovules from stem cells will be two of the greatest advances in assisted human reproduction; and it may be a reality in 2020, according to Dr. Jan Tesarik of the MARGen Clinic (Spain). The Granada scientist leads an international research program to facilitate procreation using the patient’s own genetic material, both to women with total absence or poor quality of ovules and to men who lack the spermatogenic cell line.
Jan Tesarik pioneered the birth of children from fertilized ovules “without sperm” and he did so using his precursor cells, the spermatids. He also developed the technique to obtain spermatids, by in vitro culture, from even more immature cells, called spermatocytes. “The problem – says Tesarik – is that there are men who lack both spermatids and spermatocytes, and the only possibility to have children in these cases is to go to sperm donation. The solution is to create them from the patient’s stem cells, something that can be a reality in 2020. ”
In the case of women, especially in older women, the most difficult problem to solve is the absence of ovules or the poor quality of existing ones. “In recent years – says Dr. Tesarik – we have developed different treatments that improve the probability of success in assisted reproduction of older women with their own eggs. However, none achieves the pregnancy rate of 80%, which is achieved with donated eggs. The solution to achieve these pregnancies with the genetic material itself, involves the creation of ovules from the stem cells of the patients.”
Growth hormone will be another of the main protagonists of assisted reproduction in 2020. Its use not only improves the quality of eggs, it also has positive effects for other important mechanisms involved in pregnancy, such as uterine receptivity or blood circulation in the system female player.
Recently, a series of studies have been published, coordinated by Dr. Tesarik, in which 53 Australian, Chinese, Taiwanese, American, Estonian, Danish and Spanish scientists have participated, offering the largest collection of data on the role of the hormone of growth in female reproductive function and it is planned that by 2020 these works reach clinical level, helping these women to realize their dream to become mothers.
Source: Agencia ID