Men with hypogonadism can benefit from a long-term testosterone treatment to lose weight and maintain the weight loss, according to an international study, using a 10-year ongoing observational registry of 805 men in their late-fifties to mid-sixties with hypogonadism.

Obesity is very common in men with testosterone deficiency (hypogonadism),” said lead author Karim Haider, urologist and andrologist in private practice in Bremerhaven, Germany. “Men with hypogonadism and obesity receiving long-term testosterone therapy achieved progressive and sustained weight loss, while untreated controls gained. The favorable decreases in weight and waist circumference may have contributed to the observed reductions in mortality and major cardiovascular events.”

Of the 805 men, 462 patients (57.4%) who had obesity were given the choice of being long-term treated with testosterone undecanoate injections (TU) (1,000 mg every 12 weeks). In total 273 decided to receive the testosterone treatment and 189 declined the treatment, who served as controls.

Over 10 years, the group of men who were treated with testosterone lose 20.3% of ther baseline weight, waist circumference decreased by 12.5cm in average, BMI dropped by 7.3 kg/m2, and waist-to-height ratio increased by 0.03 points.

Additionally, while in the testosterone-treated group 12 men (4.4%) died in the 10-year period of time, in the control group 57 men (30.2%) died [47 myocardial infractions (24.9%) and 44 strokes (23.3%)].

Our study found long-term testosterone therapy in men with hypogonadism and obesity resulted in significant improvement in measures of body size and composition,” Haider said. “In addition, testosterone therapy was associated with a reduced risk of death, heart attack and stroke. This suggests testosterone levels should be measured in men with obesity, and testosterone therapy should be offered if indicated.”


Source: Science Daily